PITHA: Prediction of immunogenicity for humanized and full human therapeutic antibodies

    (Academic use only)

    Name (optional):
    Organization (optional):
    E-mail address (optional):

    Please input PDB ID or your PDB file (Required)* (It must be an antibody)
    PDB ID : (e.g. 1BJ1)
    Protein Structure file: (File format must be PDB.)

    Please input Chain Names (Required) *
    Chain Names: (e.g. HL)

    Please indicate the protein structure if it is a crystal structure or a modeled structure (Required) *
    Crystal structure
    Modeled structure ****We recommend to use ABodyBuilder (http://opig.stats.ox.ac.uk/webapps/newsabdab/sabpred/abodybuilder/) for antibody structure prediction.


    * Please input the correct four-letter word shown in figure. It is case insensitivity.
    Usage: give us the antibody structures by a PDB ID or by uploading a PDB file. NOTE: Please make sure the structure is for an ANTIBODY. For NMR structures, there are multiple models in the PDB file. Please just upload one model of the NMR structure.
    Output: The output will be displayed by a web page. The output includes (1) the predicted immunogenicity: low or high; (2) the cavity volume at the CDR region; and (3) the hydrophobicity of CDR-H3 loop.

    Citation: Liang S, Zhang C (2020) Prediction of immunogenicity for humanized and full human therapeutic antibodies. PLoS ONE 15(8): e0238150. https://doi.org/10.1371/journal.pone.0238150

    Please address questions or comments to czhang5@unl.edu .

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