PITHA: Prediction of immunogenicity for humanized and full human therapeutic antibodies
(Academic use only)
Usage:
give us the antibody structures by a PDB ID or by uploading a PDB file.
NOTE: Please make sure the structure is for an ANTIBODY. For NMR structures, there are multiple models in the PDB file. Please just upload one model of the NMR structure.
Output: The output will be displayed by a web page. The output
includes (1) the predicted immunogenicity: low or high; (2) the cavity volume at the CDR region; and (3) the hydrophobicity of CDR-H3 loop.
Citation:
Liang S, Zhang C (2020) Prediction of immunogenicity for humanized and full human therapeutic antibodies. PLoS ONE 15(8): e0238150. https://doi.org/10.1371/journal.pone.0238150
Please address questions or comments to
czhang5@unl.edu .