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Transcription Factor Family: SWI/SNF-BAF60b

Kussie et al. 1996:The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind the transactivation domain of p53 and downregulate its ability to activate transcription. In certain cancers, MDM2 amplification is a common event and contributes to the inactivation of p53. The crystal structure of the 109-residue amino-terminal domain of MDM2 bound to a 15-residue transactivation domain peptide of p53 revealed that MDM2 has a deep hydrophobic cleft on which the p53 peptide binds as an amphipathic alpha helix. The interface relies on the steric complementarity between the MDM2 cleft and the hydrophobic face of the p53 alpha helix and, in particular, on a triad of p53 amino acids-Phe19, Trp23, and Leu26-which insert deep into the MDM2 cleft. These same p53 residues are also involved in transactivation, supporting the hypothesis that MDM2 inactivates p53 by concealing its transactivation domain. The structure also suggests that the amphipathic alpha helix may be a common structural motif in the binding of a diverse family of transactivation factors to the TATA-binding protein-associated factors.

There are 17 transcription factors which have been predicted for 3D structure in this family:

Transcription Factor IDGene Description
AT1G31760.1Description:   SWIB complex BAF60b domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 1;  GeneType: Protein Coding;  NCBI gene id: 840063
AT1G49520.1Description:   SWIB complex BAF60b domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 1;  GeneType: Protein Coding;  NCBI gene id: 841376
AT2G14880.1Description:   SWIB complex BAF60b domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 2;  GeneType: Protein Coding;  NCBI gene id: 815977
AT2G16480.1Description:   SWIB complex BAF60b domain-containing protein / plus-3 domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 2;  GeneType: Protein Coding;  NCBI gene id: 816146
AT2G18090.1Description:   PHD finger family protein / SWIB complex BAF60b domain-containing protein / GYF domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 2;  GeneType: Protein Coding;  NCBI gene id: 816321
AT2G35605.1Description:   SWIB complex BAF60b domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 2;  GeneType: Protein Coding;  NCBI gene id: 818127
AT3G01890.1Description:   SWIB complex BAF60b domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 3;  GeneType: Protein Coding;  NCBI gene id: 820093
AT3G03590.1Description:   SWIB complex BAF60b domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 3;  GeneType: Protein Coding;  NCBI gene id: 821215
AT3G19080.1Description:   SWIB complex BAF60b domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 3;  GeneType: Protein Coding;  NCBI gene id: 821442
AT3G48600.1Description:   SWIB complex BAF60b domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 3;  GeneType: Protein Coding;  NCBI gene id: 824020
AT4G22360.1Description:   SWIB complex BAF60b domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 4;  GeneType: Protein Coding;  NCBI gene id: 828331
AT4G26810.1Description:   SWIB complex BAF60b domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 4;  GeneType: Protein Coding;  NCBI gene id: 828788
AT4G26810.2Description:   SWIB complex BAF60b domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 4;  GeneType: Protein Coding;  NCBI gene id: 828788
AT4G34290.1Description:   SWIB complex BAF60b domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 4;  GeneType: Protein Coding;  NCBI gene id: 829579
AT5G08430.1Description:   SWIB complex BAF60b domain-containing protein / plus-3 domain-containing protein / GYF domain-containing protein;  Organism: Arabidopsis thaliana;  Chromosome: 5;  GeneType: Protein Coding;  NCBI gene id: 830742
AT5G14170.1Description:   CHC1;  Organism: Arabidopsis thaliana;  Chromosome: 5;  GeneType: Protein Coding;  NCBI gene id: 831267
AT5G63700.1Description:   zinc finger (C3HC4 type RING finger) family protein;  Organism: Arabidopsis thaliana;  Chromosome: 5;  GeneType: Protein Coding;  NCBI gene id: 836490