Transcription Factor Family: mTERF
Roberti et al. 2009: The MTERF family is a wide protein family, identified in Metazoa and plants, which consists of 4 subfamilies named MTERF1-4. Proteins belonging to this family are localized in mitochondria and have a modular architecture based on repetitions of a 30 amino acid module, the mTERF motif, containing leucine zipper-like heptads. The MTERF family includes the characterized transcription termination factors human mTERF, sea urchin mtDBP and Drosophila DmTTF. In vitro and in vivo studies show that these factors play different roles which are not restricted to transcription termination, but concern also transcription inititiation and the control of mtDNA replication. The multiplicity of functions could be related to the differences in the gene organization of the mitochondrial genomes. Studies on the function of human and Drosophila MTERF3 factor showed that the protein acts as negative regulator of mitochondrial transcription, possibly in cooperation with other still unknown factors. The complete elucidation of the role of the MTERF family members will allow to unravel the molecular mechanisms of mtDNA transcription and replication.
There are 36 transcription factors which have been predicted for 3D structure in this family:
| Transcription Factor ID | Gene Description |
| AT1G21150.1 | Description: mitochondrial transcription termination factor family protein / mTERF family protein; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 838711 |
| AT1G56380.1 | Description: mitochondrial transcription termination factor family protein / mTERF family protein; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842091 |
| AT1G61960.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842491 |
| AT1G61970.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842492 |
| AT1G61980.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842493 |
| AT1G61990.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842494 |
| AT1G62010.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842496 |
| AT1G62085.1 | Description: mitochondrial transcription termination factor family protein / mTERF family protein; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 2745844 |
| AT1G62110.1 | Description: mitochondrial transcription termination factor family protein / mTERF family protein; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842507 |
| AT1G62120.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842508 |
| AT1G62150.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842511 |
| AT1G62490.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842546 |
| AT1G74120.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 843752 |
| AT1G78930.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 844232 |
| AT1G79220.1 | Description: mitochondrial transcription termination factor family protein / mTERF family protein; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 844263 |
| AT2G03050.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 814834 |
| AT2G21710.1 | Description: EMB2219 (embryo defective 2219); Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 816708 |
| AT2G34620.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 818027 |
| AT2G36000.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 818173 |
| AT2G36000.2 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 818173 |
| AT2G44020.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 819007 |
| AT3G18870.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 821420 |
| AT3G46950.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 823848 |
| AT3G60400.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 825211 |
| AT4G02990.1 | Description: mitochondrial transcription termination factor family protein / mTERF family protein; Organism: Arabidopsis thaliana; Chromosome: 4; GeneType: Protein Coding; NCBI gene id: 828116 |
| AT4G14605.1 | Description: hypothetical protein; Organism: Arabidopsis thaliana; Chromosome: 4; GeneType: Protein Coding; NCBI gene id: 827109 |
| AT4G19650.1 | Description: hypothetical protein; Organism: Arabidopsis thaliana; Chromosome: 4; GeneType: Protein Coding; NCBI gene id: 827709 |
| AT4G38160.1 | Description: pde191 (pigment defective 191); Organism: Arabidopsis thaliana; Chromosome: 4; GeneType: Protein Coding; NCBI gene id: 829972 |
| AT4G38160.2 | Description: pde191 (pigment defective 191); Organism: Arabidopsis thaliana; Chromosome: 4; GeneType: Protein Coding; NCBI gene id: 829972 |
| AT5G06810.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 830572 |
| AT5G07900.1 | Description: mitochondrial transcription termination factor family protein / mTERF family protein; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 830684 |
| AT5G23930.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 832458 |
| AT5G45113.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 834546 |
| AT5G54180.1 | Description: PTAC15 (PLASTID TRANSCRIPTIONALLY ACTIVE15); Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 835506 |
| AT5G55580.1 | Description: mitochondrial transcription termination factor family protein / mTERF family protein; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 835652 |
| AT5G64950.1 | Description: mitochondrial transcription termination factor-related / mTERF-related; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 836619 |