Transcription Factor Family: BES1
Yin et al. 2005: Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1, accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulates gene expression is unknown. In this study, we dissect BES1 subdomains and establish that BES1 is a transcription factor that binds to and activates BR target gene promoters both in vitro and in vivo. BES1 interacts with a basic helix-loop-helix protein, BIM1, to synergistically bind to E box (CANNTG) sequences present in many BR-induced promoters. Loss-of-function and gain-of-function mutants of BIM1 and its close family members display BR response phenotypes. Thus, BES1 defines a new class of plant-specific transcription factors that cooperate with transcription factors such as BIM1 to regulate BR-induced genes.
There are 14 transcription factors which have been predicted for 3D structure in this family:
| Transcription Factor ID | Gene Description |
| AT1G19350.1 | Description: BES1 (BRI1-EMS-SUPPRESSOR 1); protein binding / transcription factor/ transcription regulator; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 838518 |
| AT1G19350.3 | Description: BES1 (BRI1-EMS-SUPPRESSOR 1); protein binding / transcription factor/ transcription regulator; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 838518 |
| AT1G19350.4 | Description: BES1 (BRI1-EMS-SUPPRESSOR 1); protein binding / transcription factor/ transcription regulator; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 838518 |
| AT1G19350.5 | Description: BES1 (BRI1-EMS-SUPPRESSOR 1); protein binding / transcription factor/ transcription regulator; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 838518 |
| AT1G19350.6 | Description: BES1 (BRI1-EMS-SUPPRESSOR 1); protein binding / transcription factor/ transcription regulator; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 838518 |
| AT1G75080.1 | Description: BZR1 (BRASSINAZOLE-RESISTANT 1); DNA binding / transcription regulator/ transcription repressor; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 843845 |
| AT1G75080.2 | Description: BZR1 (BRASSINAZOLE-RESISTANT 1); DNA binding / transcription regulator/ transcription repressor; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 843845 |
| AT1G78700.1 | Description: brassinosteroid signalling positive regulator-related; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 844206 |
| AT2G45880.1 | Description: BAM7 (BETA-AMYLASE 7); beta-amylase/ catalytic/ cation binding; Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 819196 |
| AT3G50750.1 | Description: brassinosteroid signalling positive regulator-related; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 824239 |
| AT4G18890.1 | Description: brassinosteroid signalling positive regulator-related; Organism: Arabidopsis thaliana; Chromosome: 4; GeneType: Protein Coding; NCBI gene id: 827623 |
| AT4G36780.1 | Description: transcription regulator; Organism: Arabidopsis thaliana; Chromosome: 4; GeneType: Protein Coding; NCBI gene id: 829831 |
| AT5G45300.1 | Description: BMY2 (BETA-AMYLASE 2); beta-amylase/ catalytic/ cation binding; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 834566 |
| AT5G45300.2 | Description: BMY2 (BETA-AMYLASE 2); beta-amylase/ catalytic/ cation binding; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 834566 |