Transcription Factor Family: Trihelix
Smalle et al. 1998: GT-2 is a plant transcriptional activator that contains two separate, but similar, trihelix DNA-binding domains. GT-1 is similar to GT-2, although it contains only one of such domains. cDNAs that encode GT-2 were isolated from rice (OS-GT2) and Arabidopsis (AT-GT2). Evidence is presented for the existence of an Arabidopsis gene family that is structurally related to AT-GT2. Two members of this GT2-like family, AT-GTL1 and AT-GTL2, have been isolated and characterized. Their sequences suggest that they evolved by a recent gene duplication event. Both AT-GT2 and AT-GTL genes contain an intron in the amino-terminal trihelix motif, indicating that this DNA-binding domain resulted from exon shuffling. RNA gel blot analysis using AT-GTL1 as a probe revealed four transcripts in the aerial part of the plant. All mRNA levels were significantly higher in siliques, suggesting that this gene family may function in fruit and/or seed development. To date, DNA-binding proteins characterized by the trihelix motif have been described only in plants, and may therefore be involved in plant-specific processes. Our results show that in Arabidopsis thaliana, the trihelix motif is not restricted to the GT-1 and GT-2 DNA-binding proteins.
There are 27 transcription factors which have been predicted for 3D structure in this family:
| Transcription Factor ID | Gene Description |
| AT1G13450.1 | Description: DNA binding protein GT-1; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 837905 |
| AT1G13450.2 | Description: DNA binding protein GT-1; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 837905 |
| AT1G13450.3 | Description: DNA binding protein GT-1; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 837905 |
| AT1G33240.1 | Description: AT-GTL1 (GT2-LIKE 1); DNA binding / transcription factor; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 840218 |
| AT1G54060.1 | Description: ASIL1 (ARABIDOPSIS 6B-INTERACTING PROTEIN 1-LIKE 1); sequence-specific DNA binding / transcription factor; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 841844 |
| AT1G76880.1 | Description: trihelix DNA-binding protein, putative; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 844023 |
| AT1G76890.2 | Description: GT2; transcription factor; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 844024 |
| AT2G33550.1 | Description: gt-2-related; Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 817920 |
| AT2G38250.1 | Description: DNA-binding protein-related; Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 818404 |
| AT2G44730.1 | Description: transcription factor; Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 819080 |
| AT3G10000.1 | Description: EDA31 (embryo sac development arrest 31); transcription factor; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 820161 |
| AT3G10030.1 | Description: aspartate/glutamate/uridylate kinase family protein; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 820164 |
| AT3G10030.2 | Description: aspartate/glutamate/uridylate kinase family protein; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 820164 |
| AT3G11100.1 | Description: transcription factor; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 820281 |
| AT3G14180.1 | Description: transcription factor; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 820635 |
| AT3G24490.1 | Description: transcription factor; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 822039 |
| AT3G24860.1 | Description: hydroxyproline-rich glycoprotein family protein; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 822084 |
| AT3G25990.1 | Description: DNA-binding protein GT-1-related; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 822196 |
| AT3G54390.1 | Description: transcription factor; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 824605 |
| AT3G58630.1 | Description: transcription factor; Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 825032 |
| AT5G01380.1 | Description: transcription factor; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 831895 |
| AT5G03680.1 | Description: PTL (PETAL LOSS); transcription factor; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 831757 |
| AT5G05550.1 | Description: transcription factor; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 830438 |
| AT5G05550.2 | Description: transcription factor; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 830438 |
| AT5G28300.1 | Description: trihelix DNA-binding protein, putative; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 832914 |
| AT5G47660.1 | Description: DNA-binding protein-related; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 834817 |
| AT5G63420.1 | Description: emb2746 (embryo defective 2746); DNA binding / catalytic/ hydrolase; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 836461 |