Transcription Factor Family: LOB
Husbands et al. 2007: Conserved in a variety of evolutionarily divergent plant species, LOB DOMAIN (LBD) genes define a large, plant-specific family of largely unknown function. LBD genes have been implicated in a variety of developmental processes in plants, although to date, relatively few members have been assigned functions. LBD proteins have previously been predicted to be transcription factors, however supporting evidence has only been circumstantial. To address the biochemical function of LBD proteins, we identified a 6-bp consensus motif recognized by a wide cross-section of LBD proteins, and showed that LATERAL ORGAN BOUNDARIES (LOB), the founding member of the family, is a transcriptional activator in yeast. Thus, the LBD genes encode a novel class of DNA-binding transcription factors. Post-translational regulation of transcription factors is often crucial for control of gene expression. In our study, we demonstrate that members of the basic helix-loop-helix (bHLH) family of transcription factors are capable of interacting with LOB. The expression patterns of bHLH048 and LOB overlap at lateral organ boundaries. Interestingly, the interaction of bHLH048 with LOB results in reduced affinity of LOB for the consensus DNA motif. Thus, our studies suggest that bHLH048 post-translationally regulates the function of LOB at lateral organ boundaries.
There are 49 transcription factors which have been predicted for 3D structure in this family:
| Transcription Factor ID | Gene Description |
| AT1G06280.1 | Description: LBD2 (LOB DOMAIN-CONTAINING PROTEIN 2); Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 837139 |
| AT1G07900.1 | Description: LBD1 (LOB DOMAIN-CONTAINING PROTEIN 1); Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 837305 |
| AT1G16530.1 | Description: ASL9 (ASYMMETRIC LEAVES 2 LIKE 9); Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 838223 |
| AT1G31320.1 | Description: LBD4 (LOB DOMAIN-CONTAINING PROTEIN 4); Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 840020 |
| AT1G36000.1 | Description: LBD5 (LOB DOMAIN-CONTAINING PROTEIN 5); Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 840503 |
| AT1G65620.1 | Description: AS2 (ASYMMETRIC LEAVES 2); protein binding; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842873 |
| AT1G65620.2 | Description: AS2 (ASYMMETRIC LEAVES 2); protein binding; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842873 |
| AT1G65620.3 | Description: AS2 (ASYMMETRIC LEAVES 2); protein binding; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842873 |
| AT1G65620.4 | Description: AS2 (ASYMMETRIC LEAVES 2); protein binding; Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 842873 |
| AT1G67100.1 | Description: LBD40 (LOB DOMAIN-CONTAINING PROTEIN 40); Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 843030 |
| AT1G68510.1 | Description: LBD42 (LOB DOMAIN-CONTAINING PROTEIN 42); Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 843180 |
| AT1G72980.1 | Description: LBD7 (LOB DOMAIN-CONTAINING PROTEIN 7); Organism: Arabidopsis thaliana; Chromosome: 1; GeneType: Protein Coding; NCBI gene id: 843629 |
| AT2G19510.1 | Description: LBD8 (LOB DOMAIN-CONTAINING PROTEIN 8); Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 816470 |
| AT2G19820.1 | Description: LBD9 (LOB DOMAIN-CONTAINING PROTEIN 9); Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 816501 |
| AT2G23660.1 | Description: LBD10 (LOB DOMAIN-CONTAINING PROTEIN 10); Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 816897 |
| AT2G28500.1 | Description: LBD11 (LOB DOMAIN-CONTAINING PROTEIN 11); Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 817398 |
| AT2G30130.1 | Description: ASL5; DNA binding / protein binding; Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 817565 |
| AT2G30340.1 | Description: LBD13 (LOB DOMAIN-CONTAINING PROTEIN 13); Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 817584 |
| AT2G31310.1 | Description: LBD14 (LOB DOMAIN-CONTAINING PROTEIN 14); Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 817689 |
| AT2G40470.1 | Description: LBD15 (LOB DOMAIN-CONTAINING PROTEIN 15); Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 818641 |
| AT2G42430.1 | Description: LBD16 (LATERAL ORGAN BOUNDARIES-DOMAIN 16); Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 818843 |
| AT2G42440.1 | Description: hypothetical protein; Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 818844 |
| AT2G45410.1 | Description: LBD19 (LOB DOMAIN-CONTAINING PROTEIN 19); Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 819149 |
| AT2G45420.1 | Description: LBD18 (LOB DOMAIN-CONTAINING PROTEIN 18); Organism: Arabidopsis thaliana; Chromosome: 2; GeneType: Protein Coding; NCBI gene id: 819150 |
| AT3G02550.1 | Description: LBD41 (LOB DOMAIN-CONTAINING PROTEIN 41); Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 821112 |
| AT3G03760.1 | Description: LBD20 (LOB DOMAIN-CONTAINING PROTEIN 20); Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 821165 |
| AT3G11090.1 | Description: LBD21 (LOB DOMAIN-CONTAINING PROTEIN 21); Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 820280 |
| AT3G13850.1 | Description: LBD22 (LOB DOMAIN-CONTAINING PROTEIN 22); Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 820598 |
| AT3G26620.1 | Description: LBD23 (LOB DOMAIN-CONTAINING PROTEIN 23); Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 822274 |
| AT3G26660.1 | Description: LBD24 (LOB DOMAIN-CONTAINING PROTEIN 24); Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 822278 |
| AT3G27650.1 | Description: LBD25 (LOB DOMAIN-CONTAINING PROTEIN 25); Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 822387 |
| AT3G27940.1 | Description: LBD26 (LOB DOMAIN-CONTAINING PROTEIN 26); Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 822418 |
| AT3G47870.1 | Description: LBD27 (LOB DOMAIN-CONTAINING PROTEIN 27); Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 823943 |
| AT3G49940.1 | Description: LBD38 (LOB DOMAIN-CONTAINING PROTEIN 38); Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 824156 |
| AT3G50510.1 | Description: LBD28 (LOB DOMAIN-CONTAINING PROTEIN 28); Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 824215 |
| AT3G58190.1 | Description: LBD29 (LATERAL ORGAN BOUNDARIES-DOMAIN 29); Organism: Arabidopsis thaliana; Chromosome: 3; GeneType: Protein Coding; NCBI gene id: 824988 |
| AT4G00210.1 | Description: LBD31 (LOB DOMAIN-CONTAINING PROTEIN 31); Organism: Arabidopsis thaliana; Chromosome: 4; GeneType: Protein Coding; NCBI gene id: 828114 |
| AT4G00220.1 | Description: JLO (JAGGED LATERAL ORGANS); Organism: Arabidopsis thaliana; Chromosome: 4; GeneType: Protein Coding; NCBI gene id: 828084 |
| AT4G22700.1 | Description: LBD32 (LOB DOMAIN-CONTAINING PROTEIN 32); Organism: Arabidopsis thaliana; Chromosome: 4; GeneType: Protein Coding; NCBI gene id: 828366 |
| AT4G37540.1 | Description: LBD39 (LOB DOMAIN-CONTAINING PROTEIN 39); Organism: Arabidopsis thaliana; Chromosome: 4; GeneType: Protein Coding; NCBI gene id: 829909 |
| AT5G06080.1 | Description: LBD33 (LOB DOMAIN-CONTAINING PROTEIN 33); Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 830495 |
| AT5G15060.1 | Description: hypothetical protein; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 831358 |
| AT5G35900.1 | Description: LBD35 (LOB DOMAIN-CONTAINING PROTEIN 35); Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 833576 |
| AT5G63090.1 | Description: LOB (LATERAL ORGAN BOUNDARIES); Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 836429 |
| AT5G63090.2 | Description: LOB (LATERAL ORGAN BOUNDARIES); Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 836429 |
| AT5G63090.3 | Description: LOB (LATERAL ORGAN BOUNDARIES); Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 836429 |
| AT5G63090.4 | Description: LOB (LATERAL ORGAN BOUNDARIES); Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 836429 |
| AT5G66870.1 | Description: ASL1; Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 836821 |
| AT5G67420.1 | Description: LBD37 (LOB DOMAIN-CONTAINING PROTEIN 37); Organism: Arabidopsis thaliana; Chromosome: 5; GeneType: Protein Coding; NCBI gene id: 836878 |